This article investigates the challenges confronted by students with visual impairment at the University of Cape Coast. The researchers adopted the phenomenological design and utilised semi-structured interview guide and observation guide for the data collection. Through the purposive sampling technique, the views of students with visual impairment were elicited. The findings reflect the challenges that students with visual impairment encounter while succumbing to the demands of academic endeavours at the University. These challenges are based on the inauspicious physical environment, inordinate attitude of some members of the University community and unsupportive academic arrangements at the University. The study discusses the need for public education on students with special education needs and disabilities (SEND) and the need for lecturers to reconsider their pedagogic procedures to suit all students especially students with SEND. There is also a call for the modernisation of the physical environment and academic assistive devices by the management of the University with the co-operation of the government of Ghana and some NGOs.