Objective: College students play a major role in the transmission of SARS-CoV-2, the viral agent responsible for COVID-19. We aim to understand risk perceptions, self-efficacy, and adoption of prevention behaviors in this population to inform prevention strategies. Participants: Undergraduate students attending a large public university. Methods: A convenience sample of students were surveyed (April-June 2020). Participants self-reported risk perceptions, perceived risk of contracting COVID-19, self-efficacy, and prevention behavior engagement. Results: A total of 1,449 students were included in the analysis. The majority were women (71.2%) and aged 18-24 (86.6%). Freshmen had the lowest risk and threat perceptions, as did men; men also had lower self-efficacy. Women engaged significantly more in prevention behaviors compared to men. Conclusions: Perceived risk of contracting COVID-19 was low, but overall adoption of prevention behaviors was high due to local mandates. Freshmen men were identified as having the greatest need for changing perceptions and behaviors.