Objective: This study examined provisional prevalence rates of generalized anxiety disorder (GAD) along with psychosocial correlates among U.S. college students during the first year of the pandemic. Participants: There were 1,793 undergraduate college student participants recruited from a public university. Methods: Using the Patient Health Questionnaire for GAD (GAD-7), a provisional diagnosis of GAD was determined and participants with GAD (N = 347;19.4%) and without GAD (N = 1446; 80.6%) were compared on stress, coping, loneliness, individual strength, pandemic concerns, and substance use behaviors. Results: Students with GAD symptomology reported significantly higher rates of perceived stress, greater loneliness, more fatigue, and more pandemic-related concerns. Further, those with GAD had a significant increase in substance use behaviors. Conclusions: It is important for college mental health providers to be aware of GAD symptomology among college students, and to further recognize the importance of early screening and detection, especially during traumatic stressor events.