Substantial body of empirical evidence supports the Interpersonal Theory of Suicide (IPTS; Joiner, 2005); however, the association between personality vulnerability factors and IPTS constructs had yet to be examined in Asian college students. The present study examined Blatt's (1974) model of personality in relation to Joiner's (2005) IPTS in a sample of 403 college students in Taiwan. Findings indicated that the interaction of the two interpersonal needs factors predicted suicidal ideation; the effect of the interpersonal needs factor on suicidal ideation was mainly due to perceived burdensomeness. Moreover, perceived burdensomeness emerged as the sole mediator in the link between self-criticism and suicidal ideation, as well as between dependency and suicidal ideation. The findings underscore the potential value of targeting perceived burdensomeness in suicide prevention and intervention programs for college students. Specific advice for the practice of cognitive-behavioral therapy are discussed.