As a pioneer study on academic leadership efficacy in university context, this mixed-method study aimed at exploring the association between dean leadership efficacy in the areas of action efficacy and self-regulation efficacy and the faculty level of self-efficacy in terms of teaching and research at a public university in Afghanistan. The study employed a mixed-method design to collect the required data in two different phases. First, two sets of questionnaires were used to collect the quantitative data. Second, semi-structured interviews were conducted with six faculty members to investigate their perceptions of dean leadership and the faculty efficacy so as to triangulate the quantitative results. The total participants of this study were 126 faculty members (120 for quantitative and 6 for qualitative). The results showed the dean leaders were perceived to have a medium level of leadership efficacy and the faculty were also reported with almost the same level of teaching efficacy but low level of research efficacy. A significant positive association was also found between the dean leaders and the faculty members' levels of efficacy in leadership, teaching and research. Accordingly, universities' stakeholders were addressed with certain implications about dean leadership as well as the faculty levels of efficacy.