Along with anxiety and depression, mindfulness has recently gained attention among the predictors of college adjustment. This study conducted in Türkiye, investigated the relationship between mindfulness and college adjustment through the mediating role of depression and anxiety. Data were collected using the Depression Anxiety Stress Scale, the Mindful Attention Awareness Scale, and the University Life Scale with 358 college students. College adjustment was found to be correlated positively with mindfulness and negatively with anxiety and depression. The path analysis results indicated that mindfulness predicts college adjustment while anxiety and depression served as mediator variables. Depression was found to be the best predictor of college adjustment, followed by anxiety. The path model explained 53% of the variance in college adjustment.