Children with autism spectrum disorder (ASD) who are also minimally verbal may require specialized interventions to promote the development of vocalizations. Preliminary research supports an innovative procedure called response contingent stimulus-stimulus pairing (SSP) as a potentially effective procedure to promote vocalizations. The primary aim of this study was to demonstrate the feasibility of delivering a randomized trial comparing response contingent SSP to a control condition. Secondary aims were to demonstrate the feasibility of deploying to the home environment the Digital Language Processor (DLP), a voice recorder by LENA®, and to examine preliminary efficacy of the intervention. Sixteen minimally verbal children with ASD (ages 2.0 to 3.9 years) were randomly assigned to the intervention or control condition with access to delayed treatment. Feasibility metrics were met in that 14 participants (88%) finished the study and attendance to all assessment time points and treatment sessions was over 90%. The research team conducted treatment sessions with 99% fidelity and collected 83.3% of voice recorder data. Nine of 16 caregiver satisfaction surveys were returned, and scores averaged 5.68 out of a possible 6.00 across all participants. Preliminary treatment data results showed that 8/14 participants (57%) showed significant improvement in target sounds and participants receiving the intervention were 3.5 times as likely to improve compared to control.