Given inconsistent findings in the literature as to the effects of interventions on motor skills in individuals with Down syndrome (DS), the purpose of the current study was to examine the effects of interventions on motor skills in individuals with DS by using meta-analysis procedures. A systematic database and manual search identified 15 studies meeting predetermined inclusion criteria. Hedge's g equation was used to calculate effect size for the effects of interventions on motor skills in individuals with DS. A random effect model analysis revealed a medium overall effect size for the interventions on motor skills was medium ([delta] = 0.65, SE = 0.16, p < 0.001, 95% confidence interval [0.33, 0.96]). Total dose (> 785 min) and session time (> 38 min) were significant moderators for the effects (Q = 5.00, df = 1, p = 0.03; Q = 7.12, df = 1, p = 0.008, respectively). The current meta-analysis provided support for the effectiveness of interventions on motor skills in individuals with DS. These findings should be considered when creating and developing interventions for motor skills in individuals with DS.