There is increased focus on narrowing the research-to-practice gap in education for students with autism. Positive Behavior Interventions and Supports (PBIS) is an evidence-based and widely implemented framework designed to improve outcomes for all students; however, relatively little attention has focused specifically on using the PBIS framework to guide intervention and assessment for autistic students. This commentary's purpose is to describe the utility of PBIS as a viable school-based model for the use of evidence-based practice (EBP) in autism. We aim to demonstrate how EBP for students with autism may be integrated within the PBIS framework, discuss critical concerns for students with autism within this model, and provide suggestions for future research and practice on improving educators' capacity to implement EBP for this student population.