The rise of technology and online approaches has challenged the traditional learning and teaching model for first year chemistry of formal face-to-face lectures and in-person laboratory sessions. The COVID-19 pandemic since 2020 has created a rapidly changing environment in assessment and learning experiences for students and led to rapid adoption of online technology within chemistry courses. This study, during 2019-2021, examined the implementation of an active learning platform in a large undergraduate chemistry course. This study was informed by constructivist theories of learning and of relevance was the 5E framework, with learning phases of engage, explore, explain, elaborate, and evaluate. A combination of post-survey data and coursework data were analysed. Post-survey results indicated that students positively perceived that the interactive online platform helped them to learn. User statistics data for learning and self-assessment activities affirmed that students gave priority to the self-paced interactive online approach, in preference to conventional social learning activities. Modernization of delivery of the curriculum to replace unstructured independent private study with structured learning and revision activities was of greatest benefit to student learning for lower performing students that were typically mature age students, with significant differences observed for online quiz and final exam results for this cohort of students. Overall, student learning was supported with the introduction of digital technologies in the course. The findings revealed that the self-paced learning activities for chemistry, delivered with an interactive online platform, combined with conventional learning activities can be effective in creating a culture of learning in students and maintaining academic outcomes.