ERIC Number: EJ1426143
Record Type: Journal
Publication Date: 2024-May
Pages: 14
Abstractor: As Provided
ISBN: N/A
ISSN: ISSN-0162-3257
EISSN: EISSN-1573-3432
No Differences in Auditory Steady-State Responses in Children with Autism Spectrum Disorder and Typically Developing Children
Seppo P. Ahlfors; Steven Graham; Hari Bharadwaj; Fahimeh Mamashli; Sheraz Khan; Robert M. Joseph; Ainsley Losh; Stephanie Pawlyszyn; Nicole M. McGuiggan; Mark Vangel; Matti S. Hämäläinen; Tal Kenet
Journal of Autism and Developmental Disorders, v54 n5 p1947-1960 2024
Auditory steady-state response (ASSR) has been studied as a potential biomarker for abnormal auditory sensory processing in autism spectrum disorder (ASD), with mixed results. Motivated by prior somatosensory findings of group differences in inter-trial coherence (ITC) between ASD and typically developing (TD) individuals at twice the steady-state stimulation frequency, we examined ASSR at 25 and 50 as well as 43 and 86 Hz in response to 25-Hz and 43-Hz auditory stimuli, respectively, using magnetoencephalography. Data were recorded from 22 ASD and 31 TD children, ages 6-17 years. ITC measures showed prominent ASSRs at the stimulation and double frequencies, without significant group differences. These results do not support ASSR as a robust ASD biomarker of abnormal auditory processing in ASD. Furthermore, the previously observed atypical double-frequency somatosensory response in ASD did not generalize to the auditory modality. Thus, the hypothesis about modality-independent abnormal local connectivity in ASD was not supported.
Descriptors: Children, Adolescents, Autism Spectrum Disorders, Control Groups, Auditory Perception, Auditory Discrimination, Listening Comprehension
Springer. Available from: Springer Nature. One New York Plaza, Suite 4600, New York, NY 10004. Tel: 800-777-4643; Tel: 212-460-1500; Fax: 212-460-1700; e-mail: customerservice@springernature.com; Web site: https://bibliotheek.ehb.be:2123/
Publication Type: Journal Articles; Reports - Research
Education Level: N/A
Audience: N/A
Language: English
Sponsor: Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) (DHHS/NIH); National Institute on Deafness and Other Communication Disorders (NIDCD) (DHHS/NIH); National Institute of Neurological Disorders and Stroke (NINDS) (DHHS/NIH); National Institute of Biomedical Imaging and Bioengineering (NIBIB) (NIH)
Authoring Institution: N/A
Grant or Contract Numbers: R01HD073254; R01MH117998; R21MH116517; R01DC016765; R01DC015455; R01NS104585; P41EB01589; P41EB030006