The purpose of this study was to understand the lived experience of the Spanish-speaking Latino community during the COVID-19 shelter-in-place orders. A single remote focus group meeting was conducted with nine Spanish-speaking participants to explore how residents living amidst shelter-in-place orders made informed decisions about health, safety, and security during the early months of the pandemic. The focus group meeting lasted about 60-90 minutes, and this meeting was facilitated by bilingual/bicultural Latino research assistants trained in qualitative research methods. Study participants also completed the Household Pulse Survey developed by the U.S. Census Bureau, a 20-minute survey to understand the social, health, and economic impact of COVID-19. The mean age was 33 years [range 21-60, SD = 12.44], and most participants attended some or completed a college degree. The participants self-reported as heterosexual, and five self-reported as single or never married. At least four noted making less than $25,000 annually, and four reported that they were self-employed. Most of the participants resided in New Jersey (n = 6), whereas two were from Michigan and one was from New York. The themes that emerged from the focus group meeting were the following: (1) social media and televised news outlets propagated confusing and harmful public messages; (2) COVID-19 elicited negative feelings of uncertainty; and (3) participants had widespread concerns about the health of their family, others, and self. Public messages on COVID-19 were not only confusing but harmful, as Latino families were highly dependent on them when determining how to protect their families in the early days of the pandemic.