The COVID-19 pandemic highlighted the importance of a multifaceted public health approach. Promoting health literacy and safe behaviour to reduce disease spread can be an effective social vaccine. However, the role of science teachers as part of a social vaccine is unclear. Similarly, their responses to health crises and the factors affecting such responses are poorly understood. We investigated the relationship between the COVID-19 vaccination status and the reliance on different sources of information among pre-service science teachers from South African and Indonesian universities as a preliminary effort to understand the role that teachers could play in promoting health literacy and safe behavioural practices. We conducted a survey using a comparative quantitative approach to gather data from 87 South African and 93 Indonesian pre-service science teachers through a closed-ended questionnaire. Different statistical tests were performed using SPSS to analyse the data, including the Mann-Whitney U test, Levene's test for equality of variance, t-test, regression analysis and analysis of variance. The results show that South African pre-service science teachers reported a lower COVID-19 vaccine uptake than Indonesians. Both sets of participants rely on social media, research articles, textbooks and friends and family to learn about COVID-19. However, reliance on these sources is not significantly associated with vaccination status. We conclude that contextual factors may affect vaccination status. We recommend further research into science teachers' role in promoting health literacy and safe behavioural practices to reduce the spread of diseases. We also recommend using social media to share scientific information for health education.