The paper presents a framework for school guidance in the twenty-first century that focuses the guidance approach, on promoting lifelong learning and takes into account the impact of VUCA (volatility, uncertainty, complexity, and ambiguity). It outlines the goals, objectives, and key players involved in guidance approach and provides a structured approach based on six levels: actors, devices, practices, main issues, objectives, and general aim. Four types of practices are defined to address four main societal objectives, which are linked to current challenges facing society. The framework aims to provide a tool for schools to implement and structure an educational approach to guidance.