The purpose of the study was to describe and analyze the self-efficacy of South Korean adapted physical education (APE) majors in teaching persons with disabilities. The research design was a qualitative descriptive case study. The participants were five APE majors (four men and one woman, age ranged from 20 to 25) attending a university in South Korea. The data sources were interviews, program curriculum reviews, and a researcher's journal entries; and analyzed using thematic analysis. Four themes emerged, which were: (a) determinants of self-efficacy, (b) relationships with APE faculty, (c) increased awareness, and (d) I am not confident. Findings exposed APE majors as more likely to gain confidence after volunteering to work with persons with disabilities and developing relationships with them. The results showed the importance of integrating hands-on practicum teaching experiences in APE courses for the majors to develop their positive self-efficacy in teaching persons with disabilities.