The new degree in the Global Digital Humanities has been launched by the Faculty of Humanities and Education at Mondragon University on its new urban campus of Bilbao AS Fabrik. In a time of increasing urbanisation, universities must reflect on their relationship to surrounding cities and regions and develop ways to incorporate the urban and regional setting in their educational offerings. This BA shows the value of a transdisciplinary Action Research approach in facing complex social challenges and contributing to innovative social transformations in the city and region. The new campus also marks the beginning of an internal university process to develop mutual knowledge and greater permeability between different degree programmes in pursuit of a new organisational culture and practice that moves beyond narrow disciplinary models.