Background: Tobacco use continues to be a leading cause of morbidity and mortality in the United States. Rates of tobacco use among college students remain steady with one in ten using some form of tobacco. Specific social and demographic correlates to use are needed to effectively address continued use. Purpose: The purpose of the present study was to examine specific factors associated with daily tobacco use among college students. Methods: The National College Health Assessment was disseminated in classrooms to students at one urban, Midwestern university. Results: Results indicated 8.4% of college students used some form of tobacco daily. The final model found gender and marijuana use predicted daily tobacco use. Discussion: Based on the prevalence rates found in the present study, it is evident that public health professionals are growing concerned regarding the significant adverse health effects of tobacco use. Translation to Health Education Practice: Health education programs targeting college students engaged in risky behaviors could help reduce tobacco use on college campuses. Health education interventions that address smoking cessation, alcohol, and drug abuse, and mental health support could effectively reduce daily tobacco use on college campuses.