Mental health, like many other physical diseases can contribute to a significant loss of output in our economy. Higher education institutes can play a significant role in enhancing the mental wellbeing of college students. In support of this endeavor, this research investigates how actively open-minded thinking (AOT) and spirituality (SP) relate to psychological wellbeing (PWB). Data revealed that both AOT and SP have a positive impact on most dimensions of PWB and in some instances, SP acts as a moderator. Our study highlights the importance of SP in the PWB of college students.