Background: Extensive use of social media is well-documented as being associated with poor mental health in college students. Evidence of its association with perceived stress in this population is inconclusive. Purpose: To examine the association between daily time spent on social media and perceived stress among U.S. college students. Methods: Participants were 412 students (274 females, 138 males) from the Get your Fruits and Vegetables (GetFRUVED) project in a northeastern U.S. college. Students completed the Perceived Stress Scale (PSS-14) questionnaire and reported daily minutes spent on social media. Linear regression was used to examine the association between social media use and self-reported stress. Results: Female college students who used social media for >2 h per day reported higher stress levels than students who used social media for only 0-20 min daily. Discussion: Our findings demonstrate an association between prolonged use of social media and higher stress levels among female college students. The impact of excessive social media on the stress response and psychological wellbeing should be further investigated in this population. Translation to Health Education: Practice Campus efforts toward educating college students on the positive correlation between social media use and stress are warranted, with priority given to female students.