We conducted a systematic review of telerehabilitation (TR) interventions on children and young adults with multiple disabilities (MDs). This review aimed to: (a) examine the effectiveness of telerehabilitation (TR) on adaptive skills that have been targeted for intervention; (b) describe the type of devices used in the intervention procedures; (c) summarize the outcomes; and (d) examine the consumer/professional satisfaction of TR. Eleven studies met inclusion criteria. Results suggested that TR is an effective tool in improving the adaptive skills of children and young adults with MDs. Boh consumers and professionals reported high levels of satisfaction and acceptance of TR services. Trends across different types of devices implemented in TR programs are considered and recommendations are made for future research.