Adults with autism spectrum disorder are underrepresented in the workforce. This review examined single case design research investigating vocational interventions for this population. Reporting of generalization and social validity data was also assessed. Eighteen studies met inclusion criteria. They were categorized as Behavioral Skills Training, video-based instruction, or self-management procedures. Only Behavioral Skills Training meets replication standards to be considered effective and evidence-based for this population. Video-based instruction and self-management procedures are emerging with few studies completed and variable effects. Social validity was underreported and limited in focus. Future research should include considering error correction procedures and feedback in video-based instruction, trialing self-management procedures, and greater attention to social validity.