Objective: This study examined the relationship between perceived discrimination and psychological distress among international students during the COVID-19 pandemic. Methods: A total of 188 international students from two large U.S. universities participated in the study. Perceived discrimination, psychological distress, and demographic information were assessed using self-reported questionnaires. Results: COVID-related variables and perceived discrimination were significantly associated with international students' psychological distress. Their COVID-related anxiety mediated the relationship between perceived discrimination and psychological distress. Conclusion: Initiatives to mitigate the perceived discrimination experienced by international students may improve their mental health.