Compassion and self-compassion have significant benefits for well-being and mental health. Recent literature has demonstrated that some individuals experience fear when receiving compassion from oneself or others. Fear of compassion from oneself, from others, and for others are separate but related constructs that have been strongly linked to self-criticism, depression, anxiety, and stress among college students. The present study examines how fears of compassion (measured by the Fear of Compassion scales) relate to Big Five personality traits (measured by the NEO Five Factor Inventory; Costa & McCrae, 1992) in college students. Bivariate correlational analyses revealed fear of compassion to be correlated positively with neuroticism and negatively with extraversion, agreeableness, and conscientiousness. These findings add to the literature in understanding which individuals harbor fear of compassion. Clinical implications and recommendations are discussed.