Objective: To investigate the effects of college student athletes' life skills on adaptation and life satisfaction. Participants: 246 college student athletes ("Mage" = 20.24 ± 1.11; 75% of males) who were registered in the Korea Sports Association in South Korea. Methods: A cross-sectional study design was used. College student athletes completed self-reported surveys in 2019. Study variables include life skills, adaptation to college, and life satisfaction as performed by bivariate analysis, ANOVA, and multiple regression analysis. Results: Life skills, adaptation to college, and life satisfaction were partially correlated to each other and differed by gender and sport types (p < 0.05-0.01). College student athletes' life skills were significant predictors of adaptation to college life and life satisfaction. Conclusions: Developing and establishing life skills programs in and outside of campus may help promoting college student athletes' well-being.