The recent surge of anti-lesbian, gay, bisexual, trans*, queer, intersex, and asexual+ (LGBTQIA+) state legislative bills throughout the United States prompt one to consider the multiple ways Black LGBTQIA + students in historically Black college and university (HBCU) settings will encounter challenges within and outside healthcare settings. Thus, through this innovative practice brief, we lift practical insights from the Human Rights Campaign's HBCU PrEP Peer Educator Program. We provided an overview of the peer educator program and then describe the program's components and we offered future implications for practice.