This review is an update to previous reviews and research in the area of family involvement in at-home learning. This update was needed to include additional relevant research, investigate potential moderators, and better understand when caregiver-implemented literacy interventions are most effective. This review and meta-analysis included 25 single-case design and 43 group design studies that documented the effectiveness of literacy interventions delivered at home by caregivers. The overall effect was moderate. Participant and intervention characteristics did not moderate the effects, but assessment type and methodological rigor were identified as potential moderators. These results suggest that caregivers can implement interventions at home to support their child's literacy achievement across a range of participant and intervention characteristics.