One of career counseling goals is to understand how to promote the well-being of people facing the unforeseen challenges of the changing world of work. The study investigates the relationship between psychological flexibility, career adaptability and well-being. 498 adult participants reply to Acceptance and Action Questionnaire-II, Career Adapt-Abilities Scale, Satisfaction with life scale, and Flourishing Scale. Results show that career adaptability mediates the relationship between psychological flexibility and life satisfaction as well as between psychological flexibility and flourishing, suggesting that career adaptability could be considered a personal resource that enhances the effects of psychological flexibility on hedonic and eudemonic well-being, fostering the ability to adapt to changes in self and situation. Implications for future studies and career counselling are presented.