The prevalence of mental health challenges continues to worsen among adolescents, with Black American adolescents experiencing rates of suicide attempts that are increasing faster than any other racial and ethnic groups. Research has found that the neighborhood environment impacts mental health through the type and level of stress that people experience generally. More is yet to be known, however, about the biological and psychological impacts of the neighborhood environment on stress among Black American adolescents. This study used a scoping review to explore the neighborhood environment's contribution to stress among Black American adolescent's, specifically. Seven bibliographic databases were used to identify relevant studies. Ten articles met eligibility criteria and were included in this review. Findings reveal that the biological stress response to neighborhood poverty and community violence has implications for mental and behavioral health functioning in adolescence. Implications for future research and interventions are discussed.