Among graduate social work students, experiences of childhood adversity and trauma, along with secondary exposure to others' trauma, can result in negative effects. Unaddressed, this may lead to secondary traumatic stress, burnout, or difficulty sustaining effective practice. Self-care strategies that adequately promote well-being and resilience may counter negative effects. This cross-sectional study explored associations between students' reported childhood adversity, trauma, recent stress, well-being, resilience, and perceived adequacy of self-care. Students from two public universities (N = 362) completed surveys that included measures for childhood adversity, potentially traumatic events, recent stress, secondary traumatic stress, burnout, compassion satisfaction, well-being, resilience, and perceived adequacy of self-care. Descriptive, bivariate, and multivariate analyses demonstrated students experienced higher rates of four or more adverse childhood experiences compared to the general population (34% vs. 13%); 70% reported four or more potentially traumatic events. Despite high levels of adversity and trauma, students reported average levels of personal well-being, high levels of resilience, average-to-high levels of compassion satisfaction, and low-to-average levels of secondary traumatic stress and burnout. Adversity and trauma were positively associated with secondary traumatic stress, and negatively associated with well-being. Final models suggest perceived adequacy of self-care may support well-being, resilience, and protect against negative effects.