Aligned with critical scholarship and upholding minoritized populations' agency and power, this survey research study addresses Latinx college students' resistance strategies in two Nuevo South states by examining the social issues that students are aware of, engage with, and the nature of their interactions with these issues. We apply Southern epistemology as a framework to center the unique Nuevo South sociopolitical context and examine modern issues Latinx communities face in this geographic region and how Latinx college students resist hostility. Findings empirically establish how the Southern epistemology remains to modernly construct and constrain the lives of Latinx college students in the Nuevo South.