The study aims to reveal the psychological and pedagogical indicators of self-management in a student's personality and systematize contemporary synergetic approaches for distance education. The research hypothesis suggests the possibility of optimizing students' motivation for self-management and self-learning for efficient education in a distance mode. The study's methodology is comprehensive and uses a qualitative approach. 463 students from higher institutions in Kazakhstan participated in the study. The research used a survey method in which students assessed their self-study skills. Qualitative analysis of the questionnaires made it possible to divide the respondents into three subgroups according to the results of their ability to self-study. Training and additional classes were planned and conducted in these subgroups, considering the results of the power to self-organize and self-learn, which had a positive effect. Students have different indicators of self-learning abilities, and dividing them into subgroups and differentiating the approach to organizing training has significantly increased self-learning abilities. The synergetic approach allows students to develop their self-management skills and use innovative methods to improve their subject knowledge quality. Using differentiated and synergistic approaches in online learning helps to improve the quality of learning in general.