Due to COVID-19 pandemic, using ICT for teaching purposes has been the subject of a growing field of study in educational research. Thus, this systematic review aims to provide ESP practitioners with a current synthesis of the impact of blended learning on English for specific purposes (ESP) instruction. The current study systematically reviews and synthesizes studies related to blended learning and ESP with the aim of providing a comprehensive analysis of 28 research articles published across 2012-2022 and meeting selection criteria. Findings show that blended learning can foster university ESP students' language skills. The majority of studies stress that blended learning brings considerable benefits to their ESP learning, namely flexibility, autonomy, and collaboration. The findings also revealed that few students faced some challenges such as demotivation, procrastination, and technical issues. In light of these results, the review ends up with implications for ESP teachers and researchers.