Family and school factors are among the most important determinants of internalizing and externalizing problem behavior in adolescents. The aim of this study is to explore how certain family and school factors explain internalizing and externalizing problems after one year. In addition to individual-level variables, school level variables are taken into account. This multilevel study was conducted among 507 adolescents (mean age 13.44; 52.3% girls) who reported their internalizing problems (anxiety, depressive symptoms), externalizing problems (aggressive and norm-breaking behavior), parental knowledge of their whereabouts, parental rule setting, school connectedness and teacher support. At the school level, the aggregated scores for school connectedness and teacher support were calculated. The results show that the differences between schools explained 13.4% of the variance in externalizing problem behavior although it did not account for internalizing behavior. Parental knowledge and school connectedness were significant predictors of both internalizing and externalizing problems. At the school level, aggregated teacher support predicted fewer externalizing problems. While some of the results are partially in line with previous findings, others were found to be contradictory. The implications for practice are provided.