Instructional design, development, and planning decisions are fundamental to effective online learning. However, interactions that occur within the online environment have been underestimated, despite their significance for the success of online learning. Moore (1989) suggested viewing the interactions among individuals and content in three categories: student-teacher, student-content, and student-student. The purpose of this paper is to situate the issue of quality online pedagogy within the three types of online interactions and offer specific instructional applications for effective online learning.