The Grand Challenges for Social Work were introduced by the American Academy for Social Work & Social Welfare in 2016, which are social problems that are interrelated and "exceedingly complex". We discuss the relevance of complexity theory, operationalized by complex adaptive systems (CAS), to the Grand Challenges. CAS moves beyond current ecological systems approaches and is more appropriate for studying nonlinear, dynamic phenomena such as the Grand Challenges. We explore ideas for incorporating CAS into the social work curriculum at all levels. Adopting CAS into social work practice and research via changes to the curriculum will complement current practices and can facilitate interdisciplinary research teams, and thus has tremendous promise for helping social workers address the Social Work Grand Challenges.