Learning about how economic well-being--or the lack of well-being--shapes peoples' lives can enhance social work students' and professionals' efforts to "champion social progress powered by science," a stated aim of the Grand Challenges for Social Work. Yet social work and economics have pursued divergent paths since the late 20th century, inhibiting productive collaboration. Modern, pluralist approaches to economic literacy can restart cross-disciplinary conversations by: (1) encompassing a broad range of economic activity, including nonprofits, household production, and community engagement; (2) framing well-being as the goal of economic institutions; and (3) highlighting economic policy controversies. This article illustrates how this approach informs two Grand Challenges: (1) Reduce extreme economic inequality; and (2) Create social responses to a changing environment.