The American College of St Maurice at Münster in Westphalia was founded in 1867 to train priests for the Catholic missions in the United States. This paper outlines the history of this short-lived educational institutions (1867-1879), with particular focus on the 68 seminarians, who attended this theological seminary for their pastoral formation, accompanied by scholarly studies in theology and philosophy at the Academy of Münster. This educational concept and history of the American College is considered against the background of the scholarly dispute about the dogma of papal infallibility and the Prussian "Kulturkampf," that eventually led to the closure of the American College in 1879. Finally, attention is paid to the pastoral ministry of the alumni and the situation of the German Catholics in the United States. The alumni of the American College became a particularly sought-after group of priests, not only due to their religio-cultural background, but also with regards to their broader pastoral and academic formation that helped to meet the challenges ahead.