Objective: To increase administration of influenza (flu), human papillomavirus (HPV) and meningococcal serogroup B (MenB) vaccinations to students at college student health centers (SHCs). Participants: Improvement teams from 45 US-based SHCs. Methods: Teams participated in a 7-month virtual learning collaborative to implement immunization delivery best practices at their SHCs. A pre-post-intervention design was used to compare vaccination coverage in May 2017 to May 2018 among students who were unvaccinated at the start of the academic year. Results: Data were compared from 29 SHCs and 152,648 students (2017) and from 18 SHCs and 122,315 students (2018). Percent of newly vaccinated students increased for [greater than or equal to]1 dose of flu vaccine by 14.3 percentage points to 32.3% (p < 0.01), [greater than or equal to]1 dose of HPV vaccine by 3.9 points to 7.8% (p < 0.05) and [greater than or equal to]3 doses of HPV vaccine by 0.7 points to 1.5% (p < 0.05). Conclusions: Participating in a learning collaborative may help SHCs improve vaccination delivery.