Child neglect is a problem that presents many challenges to learning and teaching in schools. Children are unable to learn if their basic needs are not met. Neglect is the second most common reason for a child to be on a child protection plan in Wales. Given the universal nature of their provision within the community, and the prevalence of neglect, schools are well-placed to notice and intervene early and provide support to children that promotes their health and wellbeing. In fact, staff in schools have the opportunity to observe children's behaviours, and their interactions with other pupils and family members up to five days a week over an extended period of time. However, little is known about the specific ways in which staff in schools respond to neglect and what factors help them to provide effective school-based support to families. This paper presents findings from thirty interviews with staff in six mainstream primary and secondary schools in Wales. Findings identify three factors that support neglect-practice within the school-setting (1) a whole-school proactive approach to child neglect; (2) a positive learning and development environment for staff members; and (3) relationships between staff and the child(ren)'s family.