Course-based undergraduate research experiences (CUREs) can engage large numbers of students and provide a structured environment in which to learn valuable research skills. The ability to implement laboratory-based CUREs was hindered by the COVID-19 pandemic, generating a greater need for online options. A pilot study of an adaptation of a fully online cancer genomics CURE is described here. Students utilized freely available databases such as cBioPortal to develop novel scientific questions, generate and analyze data, collaborate with peers, and present their findings in an online environment. This format preserved the defining aspects of CUREs while promoting student ownership over their projects. Although the most common challenge was developing a hypothesis, students valued peer and instructor feedback throughout the process as well as flexible formats for communicating their research findings.