Undergraduate courses such as biochemistry were prompted to embrace online distance learning triggered by the incursion of the COVID-19 pandemic. This study worked to help solve the issues and concerns related to teaching biochemistry as a foundational course for dental and other health-sciences programs in the status of the educational system. The case study method was deemed a good way to focus on the objectives of this research because the theme was dentistry students' perceptions and experiences dealing with the opportunities and difficulties that the COVID-19 pandemic brought with it in this circumstance. 11 purposively sampled dentistry students served as the participants of the study. Data were gathered through an online platform with open-ended questions which were thematically analyzed afterward. The identified opportunities were lumped into ROTE: Research works, Open and independent learning, Technology for education, and Education for health. Challenges encountered were grouped as DARE: Demand for technology, Acquisition of knowledge, Remote learning, and Environmental condition for studying. It is worth noting that the participants were enlightened on the academic and personal benefits of biochemistry online distance learning. The researchers appeal to future researchers and policymakers to anchor forthcoming steps to further augment the online teaching and learning experiences of teachers and learners.