Integrated Science Process Skills online learning cannot be taught optimally so learning media are needed that can teach integrated, interactive, and practical SPS. One such media is an e-module. This study aimed to determine the feasibility and effectiveness of Guided Inquiry-Based e-module, or Mosiry, in improving Integrated SPS of Class XI students in the Immune System subject. This research is a developmental research, using the 4D development design stages: 1) Defining; 2) Designing; 3) Developing; and 4) Disseminating. The sample was selected using a purposive sampling method. Data was collected by using observation, interviews, questionnaires, and pretest/post-test; and data was analysed based on media feasibility, and effectiveness analysis. The results of this study were that the Mosiry e-module is suitable for use as a learning medium for the Immune System and could improve students' SPS in the moderate category.