This purpose of this study was to explore changes in science and reading interest among a diverse group of 5th grade science students who used a mixed reality reading experience, with a specific focus on the experience of low-fluency readers. This study involved pre-post measures and post-interviews with 15 fifth grade students. The intervention was a short solo experience in which each student read a page of scientific text while wearing a Microsoft HoloLens. Inside the headset, science content came alive with 3D images, animations, and sound. Following the collection of repeated survey measures and post-interviews, a mixed methods case study indicated that students with lower reading fluency scores reported higher gains in reading and science interest. Additionally, students had a positive experience with the mixed reality and found it better than reading with a textbook or a computer screen. Low fluency readers seemed particularly impacted by the visual aspects of the technology. This study provides support for further examination of using mixed reality technology--such as Microsoft HoloLens--to increase low-fluency readers interest in science and reading.