Science continuously interacts with the social environment. Science develops with social needs, and society develops and changes with scientific advances. These changes and developments may cause dilemmas in society. Thus, the purpose of this study is to investigate the improvements among pre-service science teachers in terms of socio-scientific issues and nature of science after explicit theoretical and practical training. The participants in this case study were 16 voluntary pre-service science teachers. In-depth views of the pre-service science teachers on nature of science and socio-scientific issues were examined with open-ended questions and reflective diaries. After the training, the understanding of the pre-service science teachers for nature of science and socio-scientific issues was improved, and they learned various approaches for teaching nature of science and socio-scientific issues.