This study examines the relationship between positive mental health and educational persistence for 493 Latinx STEM students at Predominantly White Institutions (PWI) and Hispanic Serving Institutions (HSI). Results from the hierarchical multiple regression model for the HSI students found a significant relationship between educational persistence and psychological well-being while PWI students demonstrated a significant relationship between educational persistence and psychological well-being and depressive symptomatology. Implications for practice with Latinx STEM students will be discussed.