Objective: To describe extracurricular activity participation and explore its relationship with college students' health. Participants: 159 college students majoring in dental hygiene or occupational therapy. Methods: Data were collected prospectively at baseline, one- and two-year follow-ups. Self-reported participation in extracurricular activities over the past six months was grouped into eight categories: Fitness, Sports, Creative arts, Leisure, Social, Work, Caregiving, and Animal care. Physical and mental health were measured using SF-36, a valid tool measuring general health. Results: Participation in fitness, sports, creative arts, and work significantly decreased at one-year and two-year follow-ups (p < 0.01). Work/volunteer activity participation was associated with poorer physical health ([beta] = -1.4, 95% CI: (-2.2, -0.5), p < 0.01), but a change from nonparticipation to some participation in work/volunteer activity was associated with better mental health ([beta] = 2.6, 95% CI (0.3, 4.9), p = 0.04). Conclusions: Educators should consider the potential impact of maintaining extracurricular activities on college students' health when designing academic courses.