Computer-assisted instruction (CAI) gives students with visual impairment (VI) immediate access to information and enables direct collaboration with sighted educators and peers. This systematic review examined interventions addressing the impact of CAI interventions on school-age children with VI. Twenty-eight studies examined CAI interventions implemented with 339 students with VI. The CAI interventions fell into five categories: digital texts, word processors, haptic simulations, educational platforms, and serious games. Findings from this review highlight the need for: (a) addressing students' preparation or mastery for technology skills needed to participate in CAI; (b) more diverse recruitment of participants with VI; and (c) incorporating educators as implementers of CAI. Implications for practice and research are also addressed.