This study aims to describe the effect of the Nyerayo-based Science, Environment, Technology, and Society learning model on the scientific literacy skills of elementary school students in East Kluet District, South Aceh Regency. Learning Science, Environment, Technology, Society (SETS) has an important role in improving the scientific literacy and cooperation skills of Elementary School students. This research includes research that uses a quasi-experimental method with "nonequivalent control group design." The population in this study amounted to 182 fifth grade elementary school students and the sample of this study consisted of 17 male students and 37 female students with a total of 54 students. The research data was obtained through multiple choice test instruments on scientific literacy skills. The data obtained were analyzed using an independent sample t test. The results of this study indicate that "Nyerayo-based Science, Environment, Technology, and Society" learning has a significant effect on students' scientific literacy skills based on a significance value of 0.00 < 0.05.