The impact of COVID-19 on university students is multi-faceted and varies depending on the student profile. A study was conducted at a regional university in the Midwest. A quick-reaction or pulse study was done to assess the immediate effects on students in designated classes at the onset of the pandemic. A follow-up study was completed at the campus level during the subsequent fall semester. Naturally, quality of instruction and adequate technology are key to student success, but a more holistic understanding of students' lives is necessary to properly support them during challenging times. While COVID-19 provided the context for this study, the benefits of the lessons learned can be ongoing.