The purpose of this study was to investigate underlining cultural factors impeding girls' secondary education in Lilongwe Rural West Education Division (LRWED) of Malawi. Underperformance of girls in comparison to boys in their education persists. Hence the need to explore the underpinning social-cultural factors is there. The study employed a mixed methods research design. Using a multi-stage sampling approach, a sample of 295 respondents was selected from five cluster leader government secondary schools in LRWED comprising of headteachers, teachers, Form 4 female students, and parents. Data were generated through survey questionnaires, Key Informant Interviews and Focus Group Discussions (FGD). Findings indicated that key social-cultural factors affecting girls' education in LRWED include girls' initiation ceremonies, unplanned pregnancies, early marriages and poverty. Initiation ceremonies were found to contribute to early sex experimentation that undermined girls' continued interest and persistence in education through poor retention, repetition, and subsequent dropout. The findings further revealed that the absence of sex education in the schools' curriculum is the lead cause of parental dependence on local initiation ceremonies. This implies that the incorporation of cultural and sex education in schools' curricula or programs could help curb parental dependence on initiation ceremonies for girls' sex education and the challenges of early marriages and school dropout influenced by social-cultural factors.